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Andrew Chan - Several earlier studies have found that, among patients with a history of colon polyps or cancer, regular aspirin treatment prevents the recurrence of precancerous polyps. However, the ability of aspirin to reduce the long-term incidence of invasive cancer has not been well-demonstrated. Our study did find a protective effect of long-term aspirin use on risk of invasive colorectal cancer, but only at dosage levels considerably higher than those used to prevent cardiovascular disease.

Several earlier studies have found that, among patients with a history of colon polyps or cancer, regular aspirin treatment prevents the recurrence of precancerous polyps. However, the ability of aspirin to reduce the long-term incidence of invasive cancer has not been well-demonstrated. Our study did find a protective effect of long-term aspirin use on risk of invasive colorectal cancer, but only at dosage levels considerably higher than those used to prevent cardiovascular disease.

Andrew Chan
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